Because your system is comprimised, I'd recommend 1st attempting to do a complete virus scan with
Housecall. This will give you a good scan and repair, because it is not infected.
Once you have completed this, then and only then I would download a completely new copy of Highjack This and use it. I would also recommend reinstalling your anti-virus software from the CD's, and getting a firewall such as ZoneAlarm Pro.
If the above fails, then you could always backup what's important to you (remember to virus scan it later before using it) and then reformat your harddrive and reinstall Windows from the beginning.
If you choose to do that, then I'd recommend immediately updating it from the MS site, then installing a firewall and anti-virus software to secure it. Do not go anywhere on the Internet or use any old software until scanned and secured.