Spywareguard and SpywareBlaster are great tools from Javacool
I would leave them installed
You won't have problems with SpywareBlaster as it set's killbits in the registry to help prevent malware
Is SpywareGuard slowing the computer at all?
If not you can leave it installed
However, I'm not sure what AV>>Antispyware>>Firewall your running
Of course you want to keep your AV running
Keep the Firewall running also, most Firewall software when installed will disable the SP2 firewall built into Windows
You can check this in the Windows Control panel
If in fact, you have your installed Firewall running and the SP2 firewall, you should be safe turning off the SP2 firewall
Like AntiVirus software, you ONLY want one firewall running as so there are no conflicts and system instabilities
Which Antispyware product do you have installed?
I'm not sure if it will supply the same protections as spywareguard