Yep same problem. Ive tried everything, even new power supply, ide cables,motherboard, cd drives, and drivers. Nothing works. I was playing diablo 2 when this happened 2 weeks ago. I can get the cd to explore but when I want to play a game it says either 'please insert cd' or '/drive not accessible.' This is a pain in the a**. Maybe a new virus? Hope not, norton 2003 says no virus.....